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对小剂量组织型纤溶酶原激活制（ｔ－ＰＡ）重复眼内注射治疗实验性玻璃体出血的疗效进行了观察。１４只兔（２８只眼）通过向玻璃体内注入０．０５ｍｌ含枸橼酸钠的自体全血建立玻璃体出血模型。１周后将其随机分为３组，第１组和第２组隔周１次注射５μｇ或２５μｇｔ－ＰＡ共注射２次（总量１０μｇ或５０μｇ），第３组按同法接受生理盐水治疗。出血的清除在ｔ－ＰＡ治疗组均显著地快于对照组（Ｐ＜０．０５或Ｐ＜０．０１），但ｔ－ＰＡ治疗组间差异无显著性。经ＥＲＧ、光镜和电镜检查未见现网膜毒性变化。
The effect of small dose tissue plasminogen activator (t-PA) repeated intraocular injection on experimental vitreous hemorrhage was observed. Fourteen rabbits (28 eyes) A vitreous hemorrhage model was established by injecting 0.05 ml autologous whole blood containing sodium citrate into the vitreous. After 1 week, they were randomly divided into 3 groups. Group 1 and group 2 were injected once every week with 5μg or 25μgt-PA twice (total amount 10μg or 50μg), and group 3 received normal saline . Bleeding was significantly faster in the t-PA group than in the control group (P <0.05 or P <0.01), but there was no significant difference between t-PA groups. By ERG, light microscopy and electron microscopy showed no changes in retinal toxicity.