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目的:探讨女性2型糖尿病患者绝经前后血清胆固醇酯转运蛋白(CETP)活性的差异及其与代谢因素的相关关系。方法:收集2011年9月~2012年6月在南京医科大学第一附属医院内分泌科住院的113名女性2型糖尿病患者空腹血样本,整理这些患者的临床病例资料。用荧光酶法检测血样本CETP活性,并检测其他重要生化指标。结果:女性2型糖尿病人群中血清CETP活性与年龄、体质指数(BMI)、甘油三酯(TG)、空腹血糖(FBG)、糖化血红蛋白(HbA1c)呈正相关,与高密度脂蛋白胆固醇(HDL-C)呈负相关,而与收缩压(SP)、舒张压(BP)、总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)、脂蛋白(a)[Lp(a)]、空腹胰岛素、HOMA胰岛素抵抗指数(HOMA-IR)、肌酐(Cr)、尿素(Urea)、尿酸(UA)、丙氨酸氨基转移酶(ALT)、天门冬氨酸氨基转移酶(AST)、碱性磷酸酶(ALP)、直接胆红素(TBIL)没有明显相关关系。绝经前女性2型糖尿病患者血清CETP活性[(3.55±0.24)μg/ml]低于绝经后女性[(3.99±0.28)μg/ml],且差别具有统计学意义(P<0.01)。结论:女性2型糖尿病患者绝经后的CETP活性高于绝经前,且CETP活性与年龄、HDL-C密切相关。
Objective: To investigate the difference of serum cholesterol ester transfer protein (CETP) activity in women with type 2 diabetes before and after menopause and its relationship with metabolic factors. Methods: A total of 113 female patients with type 2 diabetes who were hospitalized in Department of Endocrinology, the First Affiliated Hospital of Nanjing Medical University from September 2011 to June 2012 were collected for fasting blood samples and clinical cases of these patients were collected. The CETP activity of blood samples was detected by the fluorescent enzyme method and other important biochemical indexes were detected. Results: Serum CETP activity in women with type 2 diabetes mellitus was positively correlated with age, BMI, TG, FBG and HbA1c, and was positively correlated with high density lipoprotein cholesterol (HDL- (P <0.05), but negative correlation with SBP, BP, TC, LDL-C, Lp (a) Insulin, HOMA-IR, Cr, Urea, UA, ALT, AST, Phosphatase (ALP), direct bilirubin (TBIL) no significant correlation. Pre-menopausal women with type 2 diabetes serum CETP activity [(3.55 ± 0.24) μg / ml] lower than postmenopausal women [(3.99 ± 0.28) μg / ml], and the difference was statistically significant (P <0.01). Conclusion: The CETP activity of postmenopausal women with type 2 diabetes mellitus is higher than that before menopause, and the activity of CETP is closely related with age and HDL-C.