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目的评价腹腔镜联合不同药物治疗中、重型子宫内膜异位症的疗效。方法 189例中、重型子宫内膜异位症合并不孕患者经腹腔镜手术治疗后分别联合应用甲羟孕酮、米非司酮、孕三烯酮、诺雷德治疗3个月,比较各组间的症状缓解率、复发率、妊娠率。结果术后两年,诺雷德组症状缓解率显著高于其他各组,复发率显著低于其他各组,妊娠率各组无明显差异。结论中、重型子宫内膜异位症腹腔镜手术后联合用药可改善疼痛症状,降低复发率;诺雷德在提高症状缓解率及降低复发率方面优于甲羟孕酮、米非司酮及孕三烯酮。
Objective To evaluate the efficacy of laparoscopic combined with different drugs in the treatment of severe endometriosis. Methods 189 patients with severe endometriosis and infertility were treated with laparoscopic surgery combined with medroxyprogesterone, mifepristone, gestrinone, and norethide for 3 months respectively, Symptomatic remission rate, recurrence rate, pregnancy rate. Results In the two years after operation, the symptom relief rate in Noread group was significantly higher than that in other groups, the recurrence rate was significantly lower than that in other groups, and there was no significant difference in pregnancy rate among the groups. Conclusions The combined use of laparoscopic and severe endometriosis can improve the pain symptoms and reduce the recurrence rate. Noread is superior to medroxyprogesterone and mifepristone in improving symptom relief rate and reducing recurrence rate Gestrinone.