论文部分内容阅读
顺铂是一种以二价铂与2个氯原子和2个氨分子结合的重金属络合物,自1978年第1次由FDA批准用于治疗睾丸癌和膀胱癌以来,已经应用于许多实体肿瘤的治疗,但肿瘤对顺铂耐药性的产生严重影响了其疗效[1]。虽然目前已经研发出了第3代的铂类药物,但顺铂仍然是铂类药物中应用最广、最有效的抗肿瘤药物。
Cisplatin is a heavy metal complex that combines bivalent platinum with two chlorine atoms and two ammonia molecules and has been used in many entities since it was first approved by the FDA in 1978 for the treatment of testicular and bladder cancer Cancer treatment, but the tumor resistance to cisplatin has a serious impact on its efficacy [1]. Although the third generation of platinum drugs has been developed, cisplatin is still the most widely used and most effective anti-tumor drug in platinum drugs.