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探讨幽门螺杆菌相关性胃炎中淋巴滤泡的发生率、分布及其相关病变，并评价其与临床病理学的关系。方法应用快速尿素酶试验、ＨＥ、Ｗ－Ｓ银染及ＡＢ－ＰＡＳ染色技术进行分析。结果幽门螺杆菌相关性胃炎组（ＨＰＡＧ）的淋巴滤泡（ＬＦ）发生率非常显著地高于幽门螺杆菌非相关性胃炎组（ＨＰＮＡＧ）（Ｐ＜０．０００１）。正常粘膜罕见ＬＦ。ＨＰＡＧ中的部分病人可见到ＬＦ扩大或融合、数量增加及滤泡中心细胞（ＦＣＣ）核分裂指数增加。结论ＬＦ是ＨＰＡＧ的特征性有用标记。ＬＦ及淋巴细胞广泛浸润是胃粘膜局部免疫反应形式。ＬＦ及淋巴细胞过度增殖可能是胃原发性ＭＡＬＴ淋巴瘤的危险因素。
To investigate the incidence, distribution and related pathological changes of lymphoid follicles in Helicobacter pylori-associated gastritis and to evaluate its relationship with clinical pathology. Methods Rapid urease test, HE, W-S silver staining and AB-PAS staining were used. Results The incidence of lymphatic follicles (LF) in Helicobacter pylori-associated gastritis group (HPAG) was significantly higher than that in HPNAG group (P <0.0001). Normal mucosa rare LF. In some patients with HPAG, LF enlargement or fusion, an increase in the number, and an increase in the index of mitotic central cell (FCC) mitotic index can be seen. Conclusion LF is a useful marker of HPAG. The extensive infiltration of LF and lymphocytes is a form of local immune response to gastric mucosa. LF and lymphocyte hyperplasia may be risk factors for gastric primary MALT lymphoma.