In vitro-in vivo studies of the quantitative effect of calcium, multivitamins and milk on single dos

• 作 者: Baishakhi Dey Prakash Katakam Fathi H. Assaleh Babu Rao Chandu Shanta Kumari Adiki Analava Mitra
• 机 构: School of Medical Science and Technology, I T Kharagpur, Kharagpur 721302, India“,”Faculty of Pharma
• 出 处: 药物分析学报（英文）
• 发表日期: 2015年6期
• 关键词: Ciprofloxacin Analytical methodology Bioavailability Bio-waiver Dissolution stud

Ciprofloxacin, commonly used in India as an anti-microbial for prolonged use in chronic and non-specific indications, may affect the bioavailability of the drug. The drug prescribed is commonly taken with multivitamins, calcium and milk. A simple and reliable analytical methodology obtaining a correlation with in vivo urinary excretion studies using UV and HPLC and in vitro dissolution studies (IVIVC) has shown a significant increase in elimination rate of ciprofloxacin co-administered with multivitamins, calcium and milk. Appreciable IVIVC results proved that dissolution studies could serve as an altative to in vivo bioavailability and also support bio-waivers.