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目的观察脑心通胶囊佐治脑梗死合并糖尿病的可行性、有效性。方法将脑梗死合并糖尿病患者90例按双盲法随机分为西药组和治疗组,每组45例。西药组给予奥扎格雷钠注射液治疗,治疗组在西药组基础上给予脑心通胶囊,观察2组患者治疗前后神经功能损伤程度评分,比较2组不良反应和血流变情况。结果治疗前2组患者神经损伤程度评分比较差异无统计学意义(P>0.05),治疗后2组患者的神经损伤程度评分均低于治疗前,且治疗组低于西药组,差异均有统计学意义(P<0.05)。治疗组不良反应发生率为6.7%低于西药组的15.6%,差异有统计学意义(P<0.05)。治疗组血浆黏度、纤维蛋白、全血低切黏度、全血高切黏度均低于西药组,差异均有统计学意义(P<0.05)。结论脑心通胶囊佐治脑梗死合并糖尿病患者能有效改善患者血液高凝状态,改善患者症状,减少不良反应。
Objective To observe the feasibility and effectiveness of Naoxintong capsule in treating cerebral infarction with diabetes mellitus. Methods Ninety patients with cerebral infarction and diabetes mellitus were randomly divided into western medicine group and treatment group by double-blind method, with 45 cases in each group. Ozagrel sodium injection was given to the western medicine group. The treatment group was given Naoxintong capsule on the basis of Western medicine group. The scores of neurological injury before and after treatment were observed in two groups. The adverse reaction and blood rheology were compared between the two groups. Results There was no significant difference in scores of nerve injury between the two groups before treatment (P> 0.05). After treatment, the score of nerve injury in both groups was lower than that before treatment, and the difference between the two groups was statistically significant Significance (P <0.05). The incidence of adverse reactions in the treatment group was 6.7% lower than that in the western medicine group (15.6%), the difference was statistically significant (P <0.05). Plasma viscosity, fibrin, low shear viscosity of whole blood and high shear viscosity of whole blood in treatment group were lower than those in western medicine group (P <0.05). Conclusion Naoxintong Capsule with cerebral infarction with diabetes patients can effectively improve the blood hypercoagulability in patients with symptoms and reduce adverse reactions.