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在几组实验中,用5-Fu来治疗胰腺炎证明很有希望.在狗的胰腺异体移植时,用5-Fu治疗可延长存活时间,并防止发生胰腺炎.还有其它临床研究效果良好的报道,尤其在苏联文献中报告较多,提示5-Fu有抑制DNA和RNA合成的作用,并能阻断胰腺酶合成.此外据报道,用5-Fu治疗后胰淀粉酶、胰脂肪酶、胰蛋白酶水平降低,住院时间缩短等.作者经一系列实验来测定5-Fu治疗急性胰腺炎是否有临床使用价值.作者以1979年10月——1981年10月在中芬兰中心医院62例胰腺炎病人作为研究对象.这些患者尿淀粉酶至少为正常的两倍.按住院编号将62例患
In several groups of experiments, the treatment of pancreatitis with 5-Fu proved promising.In the pancreas xenograft in dogs, treatment with 5-Fu can extend the survival time and prevent the occurrence of pancreatitis. There are other clinical studies with good results Reported in the Soviet literature in particular, suggesting that 5-Fu can inhibit DNA and RNA synthesis, and can block pancreatic enzyme synthesis.In addition, it was reported that with 5-Fu after treatment of pancreatic amylase, pancreatic lipase , Reduced trypsin levels, shorter hospital stays, etc. The authors tested whether 5-Fu treatment of acute pancreatitis has clinical value through a series of experiments.The author in 1979 October - 1981 October in Central Finland Hospital 62 cases Patients with pancreatitis as the study of these patients, urinary amylase at least twice as normal. According to the hospital number of 62 patients