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OBJECTIVE Tb investigate the expression of E-cadherin andCEA in serum in colorectal carcinoma and their relationship withliver metastasis.METHoDS CEA level was measured post-operativelyby radioimmunoassay of 60 patients with colorectal cancer.Immunohistochemical analysis was used to evaluate theexpression of E-cadherin.RESULTS In liver metastasis group,24 patients(24/26,92-3%)were high level of CEA,but only 9 patients in non-liver metastasisgroup.The difference is significant(P=0.004).Expression ofE-cadherin significantly correlated with differentiation,but wasnot associated with T ..stage or N stage Liver metastatic rate innegative expression was higher than that in positive expression.And the survival analysis showed that time of liver metastasis wassignificant different in two groups (P