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目的观察在醋酸溶液外用指引下,电灼后并皮损局部注射干扰素治疗尖锐湿疣的复发情况。方法将确诊的尖锐湿疣患者分为三组,治疗1组单纯用电离子治疗仪去除可见疣体;治疗2组在外用5%醋酸溶液后,用电离子治疗仪去除可见疣体及典型的醋酸白试验阳性的亚临床感染病灶;治疗3组在治疗2组治疗的基础上予病灶基底部局部注射重组人干扰素,隔日一次,每次100万U,连续3周。随访半年,比较三组的复发率。结果复发率在治疗1组和治疗2组之间差异有统计学意义,在治疗2组和治疗3组之间差异也有统计学意义,治疗3组的复发率最低。治疗期间患者均无严重不良反应。结论在醋酸溶液外用指引下,电灼清除可见及亚临床感染的皮损并予局部干扰素注射能明显降低尖锐湿疣的复发率,是一种有效的治疗方法。
Objective To observe the recurrence of condyloma acuminatum treated with local injection of interferon under the guidance of external application of acetic acid solution. Methods The patients with condylomata acuminatum were divided into three groups. The treatment group 1 was only treated with iontophoresis instrument to remove the visible wart. The treatment group 2 was treated with 5% acetic acid solution externally and treated with iontophoresis instrument to remove the visible wart and the typical acetic acid White test positive sub-clinical infection lesions; treatment group 3 in the treatment of two groups of treatment based on the local injection of recombinant human interferon at the base of the lesion once every other day, each 1 million U, for 3 weeks. Follow-up for six months, the recurrence rate of the three groups were compared. Results The recurrence rate was statistically significant between treatment group 1 and treatment group 2, with significant difference between treatment group 2 and treatment group 3, and treatment group 3 had the lowest recurrence rate. During the treatment of patients with no serious adverse reactions. Conclusion Under the guidance of external application of acetic acid solution, it is an effective method to remove lesions of visible and subclinical infection by electrocautery and to give local interferon injection to significantly reduce the recurrence rate of condyloma acuminatum.