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目的 动态观察肺癌患者血清可溶性细胞间粘附分子 - 1(s ICAM- 1)水平 ,明确 s ICAM- 1在肺癌发展及预后中的意义。方法 选取 2 2例未经任何治疗、组织学类型明确的肺癌 ,在动脉灌注化疗前、化疗后 2周及 8周取血 ,以 EL ISA法测定血清 s ICAM- 1水平。结果 治疗前 ,肺癌组血清 s ICAM- 1水平显著高于正常对照组[(348.4± 10 1.7) mg/ L vs(171.3± 34.2 ) m g/ L ,P <0 .0 1],血清 s ICAM- 1水平与原发灶大小呈正相关 (r=0 .6 0 14,P<0 .0 1) ;血清 s ICAM- 1水平 >30 0 mg/ L组与 <30 0 mg/ L组相比 ,前者的生存率显著低于后者 (2 6 .7%vs 85 .7% ,P<0 .0 5 )。治疗有效组化疗后 2周 s ICAM- 1水平显著低于化疗前 [(2 48.6± 46 .7) mg/ L vs (377.4±48.7) mg/ L ,P <0 .0 1],而治疗无效组 ,化疗前后 s ICAM- 1水平变化不大 (P>0 .0 5 )。结论 肺癌患者血清s ICAM- 1水平与体内肿瘤负荷、临床病期及癌细胞类型有关 ,血清 s ICAM- 1水平可作为疗效评估及预后的指标之一。
Objective To observe the level of serum soluble intercellular adhesion molecule - 1 (s ICAM - 1) in patients with lung cancer and to determine the significance of s ICAM - 1 in the development and prognosis of lung cancer. Methods Twenty-two non-HCC patients with histological type lung cancer were selected. Blood samples were taken before arterial infusion chemotherapy and two weeks and eight weeks after chemotherapy. The level of serum ICAM-1 was measured by ELISA. Results Before treatment, the level of serum s ICAM-1 in lung cancer patients was significantly higher than that in healthy controls [(348.4 ± 10 1.7) mg / L vs (171.3 ± 34.2) mg / L, P <0.01] 1 level was positively correlated with the size of the primary tumor (r = 0.6014, P <0.01); serum ICAM-1 level> 30 0 mg / L group was significantly higher than that of the <30 0 mg / The former survival rate was significantly lower than the latter (26.7% vs 85.7%, P <0.05). The level of ICAM-1 at 2 weeks after chemotherapy in the treatment-effective group was significantly lower than that before chemotherapy [(486 ± 46.7) mg / L vs (377.4 ± 48.7) mg / L, P <0.01] There was no significant difference in s ICAM-1 levels between before and after chemotherapy (P> 0.05). Conclusion The level of serum s ICAM-1 in lung cancer patients is related to the tumor burden, clinical stage and the type of cancer cells in vivo. The level of s ICAM-1 in serum can be used as one of the indicators of efficacy evaluation and prognosis.