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目的：评价卡维地洛联合替米沙坦治疗顽固性高血压的疗效及其对糖脂代谢的影响。方法130例顽固性高血压患者给予卡维地洛联合替米沙坦治疗，分别于治疗前1 d 和治疗后28 d 检测血压水平、糖脂代谢情况。结果治疗后患者的收缩压，舒张压，餐后2 h 血糖（PG），空腹血胰岛素（F Ins），餐后2 h血胰岛素（Ins）及 HOMA -IR 水平均低于治疗前；空腹血糖（FBG）水平及三酰甘油（TG）、胆固醇（TC）、低密度脂蛋白（LDL）、高密度脂蛋白（HDL）、载脂蛋白A -Ⅰ（ ApoA -Ⅰ）、载脂蛋白 B（ ApoB）含量与治疗前的差异无统计学意义。收缩压、舒张压水平与2 h PG、F Ins、2 h Ins 及 HOMA -IR 水平呈正相关关系。结论卡维地洛联合替米沙坦治疗顽固性高血压能够降低血压水平、改善血糖代谢和胰岛素抵抗。“,”Objective To study the curative effect of carvedilol com-bined with telmisartan on refractory hypertension and its influence on glu -cose and lipid metabolism.Methods One hundred and thirty patients with refractory hypertension were enrolled and given carvedilol combined with telmisartan treatment.Blood pressure, glucose and lipid metabolism were detected one day before treatment and 28 days after treatment. Results After treatment, systolic blood pressure, diastolic blood pres-sure, the levels of 2 h postprandial blood glucose (2 h PG), fasting insu-lin(F Ins), 2 h postprandial insulin (2 h Ins), insulin resistance index (HOMA -IR)were lower than those before treatment; fasting blood glu-cose(FBG) and cholesterol(TC),triglyceride(TG), low densith lipopro-tein( LDL), high densith lipoprotein ( HDL), apolipoprotein A -Ⅰ(ApoA -Ⅰ), apolipoprotein B(ApoB) content had no significant differ-ence compared with those before treatment .Systolic blood pressure and diastolic blood pressure were positively correlated with the levels of 2 h PG, F Ins, 2 h Ins and HOMA -IR.Conclusion Carvedilol combined with telmisartan have positive value for the treatment of refractory hyper -tension,as it can reduce the level of blood pressure , and improve blood glucose and insulin resistance.