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目的探讨新疆糖尿病高发民族维吾尔族中的糖尿病高危人群以及是否有糖尿病高危因素。方法收集新疆和田地区维吾尔族2型糖尿病家系21个,共372例,男159例,女213例。按与先证者血象关系远近分为3组,分别为同胞组(61例)、子代及亲代组(26例)、三级亲属组(82例),另设糖尿病家族中非血缘关系的非糖尿病患者,设为对照组(78例),观察各组的血糖、血脂、胰岛素等指标。结果同胞组体质量指数明显高于其他3组,同胞组收缩压高于三级亲属组,但与子代及亲代组差异无显著性意义(P>0.05)。同胞组与子代及亲代组之间胆固醇、三酰甘油、高密度脂蛋白胆固醇、低密度脂蛋白胆固醇差异均无显著性意义(P>0.05)。同胞组的胆固醇、低密度脂蛋白胆固醇高于三级亲属组(q=4.75,P<0.05)。同胞组与正常对照组胆固醇、高密度脂蛋白胆固醇、低密度脂蛋白胆固醇差异无显著性意义(P>0.05),同胞组三酰甘油[(1.74±0.69)mmol/L]高于正常对照组[(1.47±0.89)mmol/L](q=5.43,P<0.01)。各组间空腹血糖及负荷后血糖差异无显著性意义(P>0.05);同胞组空腹胰岛素[(14.67±11.88)mmol/L]显著高于正常对照组[(9.62±6.79)mmol/L](q=7.97,P<0.01);同胞组和子代及亲代组的负荷后胰岛素水平相同,但显著高于三级亲属组(q=5.35,P<0.01)。结论维吾尔族2型糖?
Objective To investigate the high-risk population of diabetes and the risk factors of diabetes in ethnic Uygur with high prevalence of diabetes in Xinjiang. Methods A total of 21 Uygur type 2 diabetes families were collected in Hetian area, including 372 cases, 159 males and 213 females. According to the relationship with the blood of probands, the blood relationship was divided into three groups: sibling group (61 cases), offspring and parental group (26 cases), third-degree relatives group (82 cases), and diabetes-related non-blood relationship Non-diabetic patients, as the control group (78 cases), observed in each group of blood glucose, lipids, insulin and other indicators. Results The body mass index of sibling group was significantly higher than that of the other three groups. The systolic blood pressure of sibling group was higher than that of third-degree relatives, but there was no significant difference between sibling group and progeny group (P> 0.05). There were no significant differences in cholesterol, triglyceride, high density lipoprotein cholesterol, and low density lipoprotein cholesterol between siblings and offspring and their parents (P> 0.05). The sibling group had higher cholesterol and LDL cholesterol than the third-degree relatives (q = 4.75, P <0.05). There were no significant differences in cholesterol, HDL-C and LDL cholesterol between sibling group and normal control group (P> 0.05), while sibling triglyceride (1.74 ± 0.69) mmol / L was higher than that of normal control group [(1.47 ± 0.89) mmol / L] (q = 5.43, P <0.01). There was no significant difference between the fasting blood glucose and post-loading blood glucose among the three groups (P> 0.05); fasting insulin [(14.67 ± 11.88) mmol / L] in the sib group was significantly higher than that in the normal control group [(9.62 ± 6.79) mmol / L] (q = 7.97, P <0.01). The insulin levels after loading in the sibling group, the offspring and the parental group were the same but significantly higher than those in the third-degree relatives (q = 5.35, P <0.01). Conclusion Uygur type 2 sugar?