Design, synthesis and biological activity of some novel benzimidazole derivatives against Coxsackie

• 作 者: Zhong Lv Zhang Zhi Jie Sun Fei
• 机 构: SchoolofChemistryandChemicalEngineering,SchoolofLifeScienceandEnvironmentalScience,cInstituteofMedic
• 出 处: 中国化学快报：英文版
• 发表日期: 2009年8期
• 关键词: 苯并咪唑衍生物 生物活性 病毒 合成 设计 VERO细胞 利巴韦林 中国化学会 Benzimidazole Coxsackie virus B3 （CVB3）

<正>A series of novel benzimidazole derivatives was synthesized and their anti-Coxsackie virus B_3(CVB_3) activity was evaluated in VERO cells.Compounds 9 and 10 exhibited better inhibitory activity than those of ribavirin(RBV) with IC_(50) values of