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目的：探讨慢性缺氧和营养不良对膈肌肌电图（EMGdi）和膈肌功能的影响及三普红景天保护膈肌功能的作用;方法：将32只Wistar大鼠随机分为慢性缺氧组（模拟海拔5000m，每日8小时，A组）、营养不良组（每日进正常食量1／2，B组）、缺氧加红景天组（缺氧方法同A组，每日缺氧前灌服三普红景天1.0g·kg-1，C组）和正常对照组（D组），每组8只。5周后在麻醉下测体重、EMGdi和膈肌功能，处死后测膈重;结果：B组体重低于A、C、D组50％，其膈肌显著变薄，面积缩小，重量减轻。A、B组EMGdi的H／L、Fc和电刺激时膈肌最大收缩力、最大强直收缩、疲劳指数均较C、D组显著降低，强直收缩时间和疲劳时间较C、D组显著缩短，A组与C、D组和B组与C、D组之间比较均有非常显著性差异（P均＜0.01），A组与B组和C组与D组比较无显著差异;结论：慢性缺氧和营养不良能明显引起膈肌疲劳，三普红景天具有明显保护缺氧性膈肌疲劳的作用。
Objective: To investigate the effect of chronic hypoxia and malnutrition on EMGdi and diaphragmatic function and the function of Rhodiola sachalinensis to protect diaphragmatic muscle.Methods: Thirty-two Wistar rats were randomly divided into chronic hypoxia group Simulate the altitude of 5000m, 8 hours a day, group A), malnutrition group (daily intake of normal food 1/2, group B), hypoxia and Rhodiola (hypoxia method with group A, Three doses of Rhodiola rosea 1.0g · kg-1, group C) and normal control group (group D), 8 rats in each group. After 5 weeks, the body weight, EMGdi and diaphragmatic function were measured under anesthesia. The diaphragmatic weight was measured after sacrifice. Results: The body weight of group B was lower than that of group A, C and D by 50%. The diaphragmatic muscle became thinner, the area was reduced and the weight was reduced. In group A and group B, the maximal contractile force, maximal tetanus contractility and fatigue index of EMGdi in H / L, Fc and electrical stimulation were significantly lower than those in group C and D, and the durations of tonic contraction and fatigue were significantly shorter than those in group C and D There was no significant difference between group A, B, C and D (P <0.01), and there was no significant difference between group C and D (P <0.01) Oxygen and malnutrition can cause diaphragmatic fatigue, Sipu Rhodiola has a significant protective effect of hypoxic diaphragm muscle.