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目的：观察培哚普利（ｐｅｒｉｎｄｏｐｒｉｌ）对糖尿病肾病（ＤＮ）尿蛋白排泄及血压的影响。方法：将３８例ＤＮ患者分为三组，早期ＤＮ组（Ａ）、临床ＤＮ组（Ｂ）及合并高血压的临床ＤＮ组（Ｃ）。均口服培哚普利４ｍｇ／日，共６０天。于治疗前和治疗后的第３０天、第６０天检测２４小时尿蛋白定量和平均动脉压等项指标。结果：３组２４小时尿蛋白定量均较治疗前下降（Ｐ＜０．０５）。Ａ、Ｂ二组平均动脉压治疗前后比较无显著性差异，Ｃ组平均动脉压明显降低（Ｐ＜０．０５）。结论：培哚普利对ＤＮ有一定的保护作用，对尿蛋白的排泄的影响是非血压依赖性的，可能与阻止血管紧张素Ⅱ生成而降低肾小球的滤过率有关。
Objective: To observe the effects of perindopril on urinary protein excretion and blood pressure in patients with diabetic nephropathy (DN). Methods: Thirty-eight patients with DN were divided into three groups: early DN group (A), clinical DN group (B) and clinical DN group with hypertension (C). Both oral perindopril 4mg / day, a total of 60 days. Before treatment and after treatment on the 30th and 60th days, 24-hour urine protein and mean arterial pressure were measured. Results: The 24-hour urinary protein in three groups was significantly lower than that before treatment (P <0.05). There was no significant difference in mean arterial pressure between groups A and B before and after treatment, mean arterial pressure in group C was significantly lower (P <0.05). CONCLUSION: Perindopril has a protective effect on DN, and its effect on excretion of urinary protein is not dependent on blood pressure. It may be related to preventing the formation of angiotensin Ⅱ and reducing the glomerular filtration rate.