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环氧合酶-2(cyclooxygenase-2,COX-2)是诱导型酶,可被促炎细胞因子、肿瘤促进剂、有丝分裂原和生长因子等高度诱导,参与炎症反应、细胞增殖和凋亡等多种病理过程。本综述重点关注COX-2与环境因素诱导的毒性损伤中细胞内质网应激和自噬的关系,阐述micro RNA和COX-2基因PTGS2单核苷酸多态性介导的表观遗传学和遗传学调控机制,为以COX-2作为干预靶点进行环境因素诱导毒性损伤的预防提供依据。
Cyclooxygenase-2 (COX-2) is an inducible enzyme that is highly induced by proinflammatory cytokines, tumor promoters, mitogens and growth factors and is involved in inflammation, cell proliferation and apoptosis A variety of pathological processes. This review focuses on the relationship between endoplasmic reticulum stress and autophagy induced by COX-2 and environmental factors in toxic injury and elucidates the relationship between microRNA and COX-2 PTGS2 single nucleotide polymorphism-mediated epigenetics And genetic regulation mechanism, to COX-2 as an intervention target for environmental factors to induce toxic injury prevention provide the basis.