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目的 :探讨中等强度耐力性运动对去卵巢大鼠骨量减少的作用机理。方法 :成年SD大鼠去卵巢建立骨质疏松模型 ,用骨形态计量学方法 ,研究 8周的跑台运动 (2 0m/min ,1h/d ,5d/w)对大鼠胫骨近心干骺端松质骨骨量减少的影响。结果 :去卵巢安静组大鼠骨量减少 ,骨形成增加、骨吸收增加 ,为高转换型的骨代谢。运动组大鼠比去卵巢安静大鼠骨量增加 (骨小梁面积百分比 :+ 5 3% ,P <0 .0 5 ;骨小梁数目 :+ 6 9% ,P <0 .0 1) ,骨形成减少 (标记周长百分数 :- 42 % ,骨形成率 :- 36 % ,P >0 .0 5 ) ,骨吸收减少 (破骨细胞数目 :- 42 % ,P <0 .0 5 ) ,骨的高转换受到抑制 ,但仍比正常组大鼠骨量降低 (骨小梁面积百分比 :- 6 1% ,P <0 .0 1)。结论 :中等强度运动通过抑制高骨转换 ,尤其是抑制骨吸收 ,可减少去卵巢大鼠胫骨骨丢失 ,减轻骨质疏松的程度
Objective: To investigate the mechanism of moderate-intensity endurance exercise on ovariectomized rats. Methods: Osteoporosis model was established in ovariectomized adult SD rats by bone morphometry. The effects of treadmill exercise (20 m / min, 1 h / d, 5 d / w) for 8 weeks on the proximal tibial metaphyseal Bone cancellous bone loss. Results: In ovariectomized rats, bone mass decreased, bone formation increased, bone resorption increased, which was a high conversion type of bone metabolism. Compared with the ovariectomized rats, the exercise group had a greater increase in bone mass (trabecular area percentage: + 53%, P <0.05; trabecular number: + 69%, P <0.01) Bone formation decreased (percentage of labeled perimeter: -42%, bone formation rate: -36%, P> 0.05) decreased bone resorption (number of osteoclasts: -42%, P < Bone hyperostosis was inhibited, but was still lower than that in normal rats (trabecular area percentage: -6%, P <0.01). Conclusion: Moderate-intensity exercise can reduce the bone loss and reduce the degree of osteoporosis in ovariectomized rats by inhibiting high bone turnover, especially inhibiting bone resorption