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目的研究乙氧苯柳胺软膏和阳性对照药过氧苯甲酰乳膏治疗寻常性痤疮的疗效和安全性。方法采用随机、单盲、多中心和平行性的比较研究。将乙氧苯柳胺软膏或过氧苯甲酰乳膏薄层均匀涂布患处，１日３次。疗程为４周，部分病例累积用药８周。结果乙氧苯柳胺软膏治疗１１８例寻常性痤疮４周时总有效率为５８．５％，治疗５９例寻常性痤疮８周时总有效率为７２．９％；过氧苯甲酰乳膏治疗６７例寻常性痤疮４周时总有效率为７１．６％，治疗５１例寻常性痤疮８周时总有效率为７８．４％。８周内，乙氧苯柳胺软膏的不良反应发生率为９．２％；过氧苯甲酰乳膏的不良反应发生率为２５．０％。结论乙氧苯柳胺软膏治疗寻常性痤疮的疗效在４周时虽低于过氧苯甲酰乳膏，但无统计学意义，８周时两者疗效相近。８周内乙氧苯柳胺软膏的不良反应发生率明显低于过氧苯甲酰乳膏
Objective To study the curative effect and safety of anisopamine ointment and the positive control benzoyl peroxide cream in the treatment of acne vulgaris. Methods Randomized, single blind, multicenter and parallel comparative studies. The anisopamine ointment or benzoyl peroxide cream thin layer evenly coated on the affected area, 3 times a day. Course of treatment for 4 weeks, some cases cumulative medication for 8 weeks. Results The total effective rate of anisodamine ointment in treating 118 cases of acne vulgaris was 58.5% at 4 weeks, and the total effective rate was 72.9% in 59 cases of acne vulgaris treated at 8 weeks. The benzoyl peroxide cream The treatment of 67 cases of acne vulgaris at 4 weeks the total effective rate was 71.6%, 51 cases of acne treatment at 8 weeks the total effective rate was 78.4%. In 8 weeks, the incidence of adverse reactions with phenylephrine ointment was 9.2%; the incidence of adverse reactions with benzoyl peroxide cream was 25.0%. Conclusions The efficacy of bupropion ointment in the treatment of acne vulgaris is lower than that of benzoyl peroxide cream at 4 weeks, but it is not statistically significant, and the curative effect is similar at 8 weeks. Adiponectin ointment in 8 weeks the incidence of adverse reactions was significantly lower than the benzoyl peroxide cream