阿戈美拉汀多晶型研究

• 作 者: 朱建强 魏文涛 代奕 赵健 张殿镇
• 机 构: 天津泰普药品科技发展有限公司,
• 出 处: 中国药物化学杂志
• 发表日期: 2012年06期
• 关键词: 阿戈美拉汀 多晶型 抗抑郁药

目的研究抗抑郁药阿戈美拉汀的多晶型现象。方法比较阿戈美拉汀不同晶型的制备方法,采用红外光谱和粉末X-射线衍射法测定不同晶型的特征。结果发现了阿戈美拉汀的一种新晶型(Ⅹ型),并通过红外光谱和粉末Ⅹ-射线衍射法确定其不同于文献报道的Ⅰ、Ⅱ、Ⅲ、Ⅳ、Ⅴ、Ⅵ等6种晶型。结论初步稳定性研究结果表明,阿戈美拉汀Ⅹ晶型具有适合作为药物应用的潜力。

Objective To study the polymorphism of agomelatine, an antidepressant drug. Methods The preparation methods of different crystal forms of agomelatine were compared. The characteristics of different crystal forms were determined by infrared spectroscopy and powder X-ray diffraction. As a result, a new crystalline form of agomelatine (type X) was found and was identified by IR and powder X-ray diffractometry to be different from those reported in the literature such as Ⅰ, Ⅱ, Ⅲ, Ⅳ, Ⅴ, Ⅵ Seed crystal type. Conclusions Preliminary stability studies have shown that agomelatine Form X is potentially suitable as a drug.