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目的比较奥曲肽静脉持续泵入与皮下注射2种给药途径治疗老年急性非暴发性胰腺炎(non-fulminant acute pancreatitis,NFAP)的疗效差异。方法将88例老年NFAP按奥曲肽给药途径不同分为奥曲肽静脉持续泵入组与皮下注射组。分别按下列指标评估:腹痛消失天数,恶心、呕吐消失天数,上腹压痛缓解天数,体温恢复天数,并发症发生率,总有效率。结果症状、体征消失时间奥曲肽持续静脉泵入组短于奥曲肽皮下注射组,P<0,05;并发症发生率持续静脉泵入组为6.81%(3/44),皮下注射组为11.36%(5/44),P<0.05;总有效率持续静脉泵入组为93.18%(41/44),皮下注射组为81.81(36/44),P<0.05。结论奥曲肽治疗NFAP其静脉持续泵入较皮下注射给药疗效更好,有利于缩短病程,改善预后。
Objective To compare the curative effects of continuous intravenous injection of octreotide and subcutaneous injection on the treatment of senile acute non-fulminant acute pancreatitis (NFAP). Methods Seventy eight elderly NFAP patients were divided into octreotide intravenous infusion group and subcutaneous injection group according to the route of octreotide administration. According to the following indicators were assessed: the number of days disappeared abdominal pain, nausea, vomiting disappeared days, the number of days to alleviate the pressure on the abdomen, body temperature recovery days, the incidence of complications, the total effective rate. Results Symptoms and signs of disappearance time octreotide sustained intravenous injection group shorter than octreotide subcutaneous injection group, P <0,05; incidence of complications was 6.81% (3/44) of continuous intravenous infusion group, subcutaneous injection group was 11.36% ( 5/44), P <0.05. The total effective rate was 93.18% (41/44) in continuous intravenous infusion group and 81.81 (36/44) in subcutaneous injection group, P <0.05. Conclusion Octreotide treatment of NFAP continuous intravenous pump than subcutaneous injection of better efficacy, help to shorten the course of the disease, improve the prognosis.