Cis-2-dodecenoic Acid Mediates Its Synergistic Effect with Triazoles by Interfering with Efflux Pump

• 作 者: YANG Dong Liang HU Yan Ling YI
• 机 构: KeyLaboratoryforOrganicElectronics&,InformationDisplays（KLOEID）andInstituteofAdvancedMaterials（IA
• 出 处: 生物医学与环境科学:英文版
• 发表日期: 2019年3期
• 关键词: C. ALBICANS Cis-2-dodecenoic acid azole-resistant Combination MDR1 CDR1
• 基金项目: the National Natural Science Foundation of China [81273409],the Program for Changjiang Scholars and Innovative Research Team in University [IRT_15R37],the Ministry of Science and Technology of China [

Objective To evaluate the synergy of the Burkholderia signaling molecule cis-2-dodecenoic acid (BDSF) and fluconazole (FLU) or itraconazole (ITRA) against two azole-resistant C. albicans clinical isolates in vitro and in vivo. Methods Minimum inhibitory c