Syntheses and Bioactivity of 4＂-Sulfonate-5-triphenyl silyl Avermectin B1a and Ivermectin B1a Deriva

• 作 者: LIAOLian-an FANGHong-yun LIZhe
• 机 构: DepartmentofChemisty,NationalKeyLaboratoryofElemento-OrganicChemistry
• 出 处: 高等学校化学研究：英文版
• 发表日期: 2004年5期
• 关键词: 合成 生物活性 4"-磺酸-5-三苯基甲硅烷 AVERMECTIN B1a衍生物 IVERMECTIN B1a衍生物 杀虫活性 质谱 核磁共振 大环内
• 基金项目: Supported by“86 3” Program (No.2 0 0 1AA 2 35 0 11) and“973” Program (No.2 0 0 3CB114 4 0 6 )

Fourteen new derivatives of avermectin B1a, and ivermectin B1a were synthesized from C5-O-triphenyl silylavermectin B1a and ivermectin B1a (yield from 40% to 83%). Their chemical structures were characterized by means of IR. ^1H NMR, ^13C NMR and FAB-MS s