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目的：观察SD大鼠肝硬变门脉高压形成过程中TNF浓度与肝损伤的关系．方法：采用放射免疫测定法．团体t检验．结果：TNF水平（ng／L）在早（1．22±0．26）中（1．21±0．23）晚（1．23±0．17）三期肝硬变中与正常组（0．97±0．23）相比明显升高（P＜0．05）；与门脉压力变化无明显相关．结论：TNF水平升高，加重了肝脏损伤的肝纤维化病变与门脉压力变化无关．
Objective: To observe the relationship between TNF concentration and liver injury during the formation of portal hypertension in cirrhotic rats. Methods: Radioimmunoassay was used. Group t test. Results: The levels of TNF in the third phase of liver cirrhosis (1.22 ± 0.26) (1.21 ± 0.23) and late (1.23 ± 0.17) 0.97 ± 0.23) (P <0.05), but no significant correlation with changes of portal pressure. CONCLUSIONS: Elevated TNF levels have not been associated with changes in portal pressure in patients with liver fibrosis that aggravate liver injury.