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目的 评价3种血吸虫病免疫学诊断方法在低度流行区应用的费用-效果。方法 在江苏省江滩型血吸虫病低度流行区选择一自然人群,用胶体染料试纸条法(DDIA)、双面胶纸环卵沉淀试验(DGS-COPT)和酶联免疫吸附试验(ELISA)同时进行检测。以粪便孵化法和改良加藤氏法阳性确诊病人作为金标准,运用卫生经济学方法,评价3种免疫学诊断方法的费用-效果。结果 3种方法总费用相近,DDIA每查出1例血吸虫病人的费用和漏检病人造成的损失分别比ELISA少7.17％和200％,查出1例血清学试验阳性者费用和人均检查费用分别比ELISA多5.8％和23.16％。DGS-COPT各项费用均比DDIA和ELISA为高。粪检阳性者中,DDIA、DGS-COPT和ELISA的阳性符合率分别为94.4％、72.2％和83.3％。结论 在血吸虫病低度流行区,胶体染料试纸条法经济实用。
Objective To evaluate the cost-effectiveness of three immunological diagnostic methods for schistosomiasis in areas of low endemicity. Methods A natural population was selected in the endemic area of jiangsu type Schistosomiasis in Jiangsu Province. The results of colloidal dye strip test (DIA-DTP) and enzyme-linked immunosorbent assay (ELISA) ) At the same time testing. Taking the stool incubation method and the modified Katsisian method as the gold standard, we used the method of health economics to evaluate the cost-effectiveness of three immunological diagnostic methods. Results The total costs of the three methods were similar. The cost of one case of schistosomiasis detected by DDIA and the loss caused by undetected patients were 7.17% and 200% lower than that of ELISA respectively. One case of positive serological test and per capita examination cost were found separately 5.8% and 23.16% more than ELISA. DGS-COPT costs are higher than DDIA and ELISA. The positive coincidence rates of DDIA, DGS-COPT and ELISA were 94.4%, 72.2% and 83.3% in fecal seized patients respectively. Conclusion In the endemic area of schistosomiasis, colloidal dye test strips are economical and practical.