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目的探讨生长抑素、垂体后叶素及其联合治疗食管胃底静脉曲张破裂出血的疗效。方法 94例肝硬化食管胃底静脉曲张破裂出血患者随机分为3组。垂体后叶素组34例,6 U/h,持续静脉滴注;生长抑素组32例,250μg静脉注射后以250μg/h持续静脉滴注;联合治疗组28例,联合应用上述药物。结果垂体后叶素组、生长抑素组及联合治疗组平均止血时间分别为(33±16)h(、20±9)h及(14±9)h。3组间比较差异均有统计学意义(P<0.05),生长抑素组、联合治疗组均优于单用垂体后叶素组。结论生长抑素治疗食管、胃底静脉曲张破裂出血疗效好,不良反应相对较少。
Objective To investigate the effect of somatostatin, pituitrin and combined treatment of esophageal and gastric variceal bleeding. Methods 94 cases of liver cirrhosis esophageal varices bleeding were randomly divided into three groups. 34 cases of pituitrin, 6 U / h, continuous intravenous infusion; somatostatin group of 32 patients, 250μg intravenous injection of 250μg / h continuous intravenous infusion; combination therapy group of 28 patients, the combination of the above drugs. Results The mean hemostatic time of vasopressin group, somatostatin group and combined treatment group were (33 ± 16) h (, 20 ± 9) h and (14 ± 9) h, respectively. The differences between the three groups were statistically significant (P <0.05), somatostatin group, combined treatment group were better than pituitrin alone group. Conclusion Somatostatin is effective in treating esophageal and gastric variceal bleeding with relatively few adverse reactions.