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中国药典2000年版(二部)收载的无菌检查法中采用全封闭薄膜过滤系统,与1995年版中国药典半封闭薄膜过滤相比,有操作简单,降低染菌率等优点。 在实验中,对薄膜过滤后的残留抗生素需要用冲洗液进行冲洗,冲洗干净与否是影响实验结果准确性的关键环节,在2000年版中国药典中对冲洗液的种类数量,冲洗方法等都未做具体规定,给操作带来不便。 本文研究目的,是对中国药典2000年版(二部)收载的抗生素无菌检查法(膜过滤)品种,进行冲洗最佳条件的选择,可
The Chinese Pharmacopoeia 2000 edition (two) contained sterile test method using closed membrane filtration system, compared with the 1995 edition of the Chinese Pharmacopoeia semi-closed membrane filtration, simple operation, reducing the rate of infection and so on. In the experiment, the residual antibiotics after filtering the membrane need to be rinsed with the rinsing liquid, and whether the rinsing is clean or not is the key point that affects the accuracy of the experimental result. In the 2000 edition of Chinese Pharmacopoeia, To make specific provisions, to the inconvenience to the operation. The purpose of this study is to choose the optimum conditions for the rinse of antibiotic sterility test (membrane filtration) varieties contained in the Chinese Pharmacopoeia 2000 edition (2)