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约15％的溃疡性结肠炎病人在发病时需住院接受静脉滴注皮质类固醇治疗,而这种治疗仅对60％的病人有效,无效者常需作全结肠切除术。 环孢素可选择性抑制T淋巴细胞介导的免疫反应,对皮质类固醇治疗无效的克隆病也有效。本研究旨在评估环孢素治疗严重溃结的效果及安全性。
Approximately 15% of patients with ulcerative colitis need to be hospitalized for intravenous corticosteroid therapy at onset, and this treatment is effective only in 60% of patients, and inefficiencies are often required for total colectomy. Cyclosporine selectively inhibits T lymphocyte-mediated immune responses and is also effective in treating Crohn’s disease that is refractory to corticosteroid therapy. The aim of this study was to evaluate the efficacy and safety of cyclosporine in the treatment of severe ulceration.