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目的:观察抗宫炎片联合西药治疗宫腔粘连的临床疗效。方法:纳入208例已婚女性患者,采用随机数字分组法将患者平均分为2组各104例,同时选取104例于本站生殖健康门诊体检健康者作为健康组。观察组、对照组患者均行宫腔镜术,观察组口服抗宫炎片,对照组口服戊酸雌二醇片。分别观察受试者的治疗效果,并测定受试者血清卵泡刺激素(FSH)、黄体生成素(LH)、雌二醇(E2)、催乳素(PRL)、孕酮(P)和睾酮(T)的水平,以及雌激素受体(ER)、孕激素受体(PR)的表达。结果:观察组总有效率为96.15%,高于对照组的总有效率(72.12%),差异有统计学意义(P<0.05)。治疗后,2组各项激素水平比较,差异均无统计学意义(P>0.05)。观察组与对照组的ER水平均高于健康组(P<0.05),观察组ER与对照组比较,差异有统计学意义(P<0.05);3组PR水平比较,差异无统计学意义(P>0.05)。结论:抗宫炎片对宫腔粘连具有良好的治疗作用,有助于改善患者的激素水平和临床症状。子宫内膜中ER的异常表达可能参与宫腔粘连的形成。
Objective: To observe the clinical curative effect of anti-GongYanYan combined with western medicine in treating intrauterine adhesions. Methods: A total of 208 married female patients were enrolled in this study. The patients were equally divided into two groups (104 cases) by random number grouping method. At the same time, 104 healthy subjects were selected as the healthy group from the reproductive health clinic. The observation group and the control group patients underwent hysteroscopy, the observation group oral anti-uterine inflammation tablets, the control group oral estradiol valerate tablets. The therapeutic effects of the subjects were observed, and the levels of serum FSH, LH, PRL, P and testosterone T), as well as the expression of estrogen receptor (ER) and progesterone receptor (PR). Results: The total effective rate in the observation group was 96.15%, higher than that in the control group (72.12%), the difference was statistically significant (P <0.05). After treatment, there was no significant difference between the two groups of hormone levels (P> 0.05). The levels of ER in observation group and control group were significantly higher than those in healthy group (P <0.05). The ER in observation group was significantly higher than that in control group (P <0.05). There was no significant difference in PR level among the three groups P> 0.05). Conclusion: Kangongyan tablet has a good therapeutic effect on intrauterine adhesions, which can help to improve the hormone level and clinical symptoms of patients. Abnormal expression of ER in endometrium may participate in the formation of intrauterine adhesions.