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作者对大剂量 LRH 超活性促效剂是否能紊乱黄体功能和引起堕胎进行了研究。5例健康早孕的妇女,年龄23～37(平均31)岁,要求做治疗性流产,志愿者参加本研究,用放免法测定 HCG 确诊为妊娠。用 LRH 促效剂未引起流产的妇女同意吸宫中断妊娠。3例用有力的 LRH促效剂 D-Ser(TBU)~6-EA~(10)-LRH 50μg,每日三次,静脉注射,连用4天(总量600μg),LRH的给药时间分别是末次月经的第37,38和40天。第4例于妊娠42天接受50μg 静脉注射,由于不合作未完成疗程。第5例从妊娠第46天给药125μg,
The authors investigated whether high-dose LRH hyperactive agonists can disrupt luteal function and cause abortion. Five healthy early pregnant women, aged from 23 to 37 (mean, 31) years old, were asked to do a therapeutic abortion. Volunteers were enrolled in this study. Radiofrequency assay was used to confirm the diagnosis of HCG as pregnancy. Women who did not cause abortion with the LRH agonist agreed to abortion by abstinence from pregnancy. 3 cases were treated with potent LRH agonist D-Ser (TBU) ~ 6-EA ~ (10) -LRH 50μg intravenously three times a day for 4 days (600μg total). The administration time of LRH were The last menstruation on the 37th, 38th and 40th days. The fourth case received 50 μg intravenously on day 42 of gestation, and treatment was not completed due to lack of cooperation. The fifth case from the 46th day of pregnancy administered 125μg,