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器官缺血后的血液再灌注是必然的治疗措施,但再灌注的同时也会引起再灌注损伤,缺血再灌注损伤的治疗已成为大家关注的焦点。再灌注损伤机制中氧自由基增加,中性粒细胞浸润等起了重要的作用,因此抗氧化剂的应用逐渐受到重视。二甲基亚砜(DMSO)作为经典的抗氧化剂,近年来许多国外实验室开始关注它对器官缺血再灌注(如脑、肝、肾、胃肠、后肢、睾丸及卵巢等)损伤的治疗作用,而且目前在国外DMSO已经应用于临床脑缺血再灌注损伤的治疗中。高血压、冠心病、心肌梗死等缺血性疾病是现代社会的常见病,由此产生的心肌再灌注损伤的治疗是当务之急,希望通过本次综述为心肌缺血再灌注损伤提供一新的治疗思路。
Blood reperfusion after organ ischemia is an inevitable treatment, but reperfusion also causes reperfusion injury. The treatment of ischemia-reperfusion injury has become the focus of everybody’s attention. In the mechanism of reperfusion injury, oxygen free radicals increase and neutrophil infiltration play an important role. Therefore, the application of antioxidants has been paid more and more attention. In recent years, many foreign laboratories have begun to pay attention to the treatment of organ ischemia-reperfusion injury (such as brain, liver, kidney, gastrointestinal, hind limb, testis and ovary) as a classic antioxidant. Role, and currently in foreign DMSO has been used in the treatment of clinical cerebral ischemia-reperfusion injury. Hypertension, coronary heart disease, myocardial infarction and other ischemic diseases is a common disease in modern society, the resulting myocardial reperfusion injury is a priority, hoping to provide a new treatment for myocardial ischemia-reperfusion injury through this review Ideas.