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目的研究空芯针穿刺活检术(CNB)在乳腺癌术前诊断中的准确性和可靠性。方法回顾性分析61例乳腺癌患者术前CNB以及术后切除标本的病理组织学结果,并采用免疫组织化学法检测雌激素受体(ER)、孕激素受体(PR)和人表皮生长因子受体2(HER-2)的表达水平。结果乳腺癌患者术前CNB与术后切除标本的病理组织学诊断结果相符率为93.4%,两者病理分级一致率为77.2%(κ=0.60,P<0.01),ER、PR、HER-2表达的一致率分别为87.7%、82.5%、63.2%(κ=0.75、0.62、0.46,P<0.01)。结论术前CNB诊断乳腺癌安全、可靠。
Objective To study the accuracy and reliability of core needle biopsy (CNB) in preoperative diagnosis of breast cancer. Methods The histopathological changes of preoperative CNB and resected specimens of 61 breast cancer patients were retrospectively analyzed. The expressions of estrogen receptor (ER), progesterone receptor (PR) and human epidermal growth factor Receptor 2 (HER-2) expression levels. Results The coincidence rate of histopathological diagnosis of preoperative CNB and postoperative resected specimens was 93.4% in breast cancer patients. The consistency rate of pathological grade was 77.2% (P <0.01), ER, PR, HER-2 The concordance rate of expression was 87.7%, 82.5%, 63.2% (κ = 0.75,0.62,0.46, P <0.01). Conclusion Preoperative CNB diagnosis of breast cancer is safe and reliable.