论文部分内容阅读
目的:代谢综合征(metabolic syndrome,MS)可能与乳腺癌的发生相关。本研究探讨MS在乳腺疾病病人中的发生情况,及与乳腺癌发生之间的关系。方法:选取2012年12月至2015年3月在上海瑞金医院乳腺疾病诊治中心手术的乳腺疾病病人,检测并收集病人的体质量指数(body mass index,BMI)、血压、血脂、血糖和临床资料,比较其在乳腺良、恶性疾病病人中的差异。结果:共有2 816例病人,乳腺良性和恶性病人分别为1 500例和1 316例,其BMI分别为(22.8±3.1)和(23.4±3.2)(P=0.018);伴MS人数分别有131例(8.7%)和191例(14.5%)(P<0.001)。单因素分析显示,MS和肥胖等代谢紊乱在乳腺良、恶性疾病组间差异有统计学意义(P<0.05)。多因素分析显示,代谢紊乱中仅肥胖(P=0.010)是乳腺癌发生的独立影响因素。与BMI<25.0的女性相比,肥胖女性具有更高的乳腺癌患病风险(OR=1.28,95%CI=1.06~1.56)。结论:有14.5%的乳腺癌病人存在MS,较乳腺良性疾病病人合并MS高;肥胖可能增加乳腺癌的发生,值得进一步研究证实。
Objective: Metabolic syndrome (MS) may be related to the occurrence of breast cancer. This study explored the incidence of MS in patients with breast disease and its relationship with the development of breast cancer. Methods: Patients with breast diseases undergoing surgery at the Breast Disease Center of Shanghai Ruijin Hospital from December 2012 to March 2015 were selected and their body mass index (BMI), blood pressure, blood lipids, blood glucose and clinical data were collected and analyzed. , Compare their differences in patients with benign and malignant breast disease. RESULTS: A total of 2 816 patients with benign and malignant breast tumors were 1 500 and 1 316, respectively, with BMIs of (22.8 ± 3.1) and (23.4 ± 3.2), respectively (P = 0.018). The number of MS with MS was 131 Cases (8.7%) and 191 cases (14.5%) (P <0.001). Univariate analysis showed that metabolic disorders such as MS and obesity had significant difference between benign and malignant breast diseases (P <0.05). Multivariate analysis showed that obesity (P = 0.010) in metabolic disorders was an independent predictor of breast cancer. Compared with women with BMI <25.0, obese women had a higher risk of breast cancer (OR = 1.28, 95% CI = 1.06 ~ 1.56). Conclusion: There are 14.5% of breast cancer patients with MS, compared with benign breast disease patients with MS high; obesity may increase the incidence of breast cancer, it is worth further study confirmed.