Understanding super-enhancers

• 作 者: Hao Cheng Xiaoyang Dou Jing-Do
• 机 构: KeyLaboratoryofComputationalBiology
• 出 处: 中国科学：生命科学英文版
• 发表日期: 2016年3期
• 关键词: 超促进剂 基因表达 分子机制 生物环境 定义 细胞 激活
• 基金项目: This work was supported by the National Natural Science Foundation of China （31210103916, 91329302 and 91519330）,the Progress on CAS Strategic Priority Research Program （XDAOIOI0303） and the Instrumen

<正>Super-enhancers are defined as cluster of enhancers with dense TF binding,which can activate proximal cell-identity gene expression.Here we review the identification,functional significance of super-enhancers,and their relationships with cancer.W