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目的:探讨支气管鼻病毒感染与哮喘患儿发病的相关性。方法:选择2012年8月至2015年3月在医院治疗的45例哮喘急性发作期患儿为哮喘发作组和45例哮喘缓解期患儿为哮喘缓解组,并选择同期40例健康体检儿童作为正常组;采用PCR法对鼻病毒基因进行检测以判定患儿感染,采用全血细胞分析仪测定外周血嗜酸性粒细胞(EOS)计数,采用化学发光免疫分析仪测定血清总免疫球蛋白E(T-IgE),对T-IgE与EOS进行相关性分析。结果:哮喘发作组鼻病毒感染14例占31.11%,明显高于对照组0例占0.00%和哮喘缓解组3例占6.67%,差异均有统计学意义(P均<0.05),而哮喘缓解组鼻病毒感染率较对照组无明显变化,差异无统计学意义(P>0.05)。哮喘发作组和哮喘缓解组血清T-IgE与EOS明显高于正常组,差异有统计学意义(P<0.05);而哮喘发作组血清T-IgE与EOS明显高于哮喘缓解组,差异有统计学意义(P<0.05)。哮喘发作组鼻病毒感染患儿血清T-IgE与EOS明显高于非鼻病毒感染患儿,差异具有统计学意义(P<0.05)。正常组患儿血清T-IgE与EOS无相关性(r=0.325,P>0.05);哮喘发作组血清T-IgE与EOS正相关性(r=0.736,P<0.05);哮喘缓解组血清T-IgE与EOS正相关性(r=0.613,P<0.05);哮喘发作组鼻病毒感染患儿血清T-IgE与EOS无相关性(r=0.316,P>0.05),非鼻病毒感染患儿血清T-IgE与EOS正相关性(r=0.674,P<0.05)。结论:鼻病毒感染与儿童哮喘的严重程度有关,且患儿的血清T-IgE越高,越容易发生鼻病毒感染,导致哮喘病情加重。
Objective: To investigate the relationship between bronchopneumonia virus infection and asthma in children. Methods: Forty-five children with asthma exacerbation who were treated in the hospital from August 2012 to March 2015 were selected as asthma attack group and 45 children with asthma remission as asthma relief group. Forty healthy children Normal group. PCR method was used to detect the rhinovirus gene to determine the infection in children. The count of peripheral blood eosinophils (EOS) was determined by the whole blood cell analyzer. The total immunoglobulin E (T -IgE), T-IgE and EOS correlation analysis. Results: In the asthma attack group, rhinovirus infection accounted for 31.11% in 14 cases, significantly higher than that in control group (0%) and asthma relief group (6.67%), the differences were statistically significant (P <0.05) There was no significant difference in the infection rate of rhinovirus between the control group and the control group (P> 0.05). Serum T-IgE and EOS in the asthma attack group and the asthma relief group were significantly higher than those in the normal group (P <0.05), while the serum T-IgE and EOS in the asthma attack group were significantly higher than those in the asthma relief group Significance (P <0.05). Serum T-IgE and EOS in asthmatic children with rhinovirus infection were significantly higher than those in non-rhinovirus infected children, the difference was statistically significant (P <0.05). There was no correlation between serum T-IgE and EOS in children with normal asthma (r = 0.325, P> 0.05). There was a positive correlation between serum T-IgE and EOS in asthmatic children (r = 0.736, (R = 0.613, P <0.05). There was no correlation between serum T-IgE and EOS in asthmatic children with rhinovirus infection (r = 0.316, P> 0.05) Serum T-IgE was positively correlated with EOS (r = 0.674, P <0.05). Conclusion: Rhinovirus infection is related to the severity of childhood asthma. The higher the serum T-IgE in children, the more susceptible to rhinovirus infection, resulting in aggravation of asthma.