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自从1969年 Rygaard和 Povlsen首次报道人结肠癌裸小鼠移植成功以来,至今几乎所有人类恶性肿瘤均可在裸小鼠成功移植。但国内外关于人鼻咽癌组织裸小鼠移植成功的报道仍很少。作者自1985年底至今曾将38例人鼻咽癌活检组织接种于探小鼠进行移植研究,其中有一例获成功并已在裸鼠间连续传九代,建立了人鼻咽癌裸鼠移植瘤——湛江1(Nasopharyngeal Carcinoma-Nude mice-Z1)。现将该移植瘤的建立过程及其某些生物学特性初步研究结果报道如下。
Since Rygaard and Povlsen first reported the successful transplantation of nude mice with colon cancer in 1969, almost all human malignancies have been successfully transplanted in nude mice. However, there are still few reports on successful transplantation of human nasopharyngeal carcinoma tissues in nude mice at home and abroad. Since the end of 1985, the author had 38 cases of human nasopharyngeal cancer biopsy inoculated in the probe mice for transplantation studies, one of which was successful and has been passed between the nude mice for nine generations, established a human nasopharyngeal carcinoma transplanted in nude mice - Nasopharyngeal Carcinoma-Nude mice-Z1. The preliminary study results of the establishment of the transplanted tumor and some of its biological characteristics are reported below.