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目的观察支气管肺炎患儿血清半胱氨酸蛋白酶抑制剂C(serum cystatin C,SCys C)水平变化及其临床意义。方法支气管肺炎患儿50例(观察组)依据疾病程度分为轻度支气管肺炎组(26例)和重度支气管肺炎组(24例),同期择期行腹股沟疝修补手术患儿22例为对照组,检测并比较各组SCys C、尿素氮、血清肌酐水平。结果支气管肺炎患儿SCys C水平高于对照组(P<0.05),重度支气管肺炎组SCys C水平高于轻度支气管肺炎组(P<0.01);重度支气管肺炎组血清肌酐水平高于对照组(P<0.05);3组尿素氮水平比较差异无统计学意义(P>0.05);轻度支气管肺炎组SCys C、血清肌酐的AUC分别为0.709,0.587;重度支气管肺炎组SCys C、血清肌酐的AUC分别为0.834,0.715。结论 SCys C可作为支气管肺炎患儿早期肾损伤的诊断指标之一。
Objective To observe the changes of serum cystatin C (SCys C) in children with bronchopneumonia and its clinical significance. Methods Fifty children with bronchopneumonia (observation group) were divided into mild bronchopneumonia (26 cases) and severe bronchopneumonia (24 cases) according to the degree of disease. Twenty-two children underwent inguinal hernia repair operation at the same period as control group, The levels of SCys C, urea nitrogen and serum creatinine in each group were detected and compared. Results The levels of SCys C in children with bronchopneumonia were significantly higher than those in control group (P <0.05). The levels of SCys C in severe bronchial pneumonia group were higher than those in mild bronchopneumonia group (P <0.01) P <0.05). There was no significant difference in the levels of urea nitrogen among the three groups (P> 0.05). The AUC of SCys C and serum creatinine in mild bronchopneumonia group were 0.709 and 0.587, respectively. The levels of SCys C, serum creatinine AUC were 0.834,0.715. Conclusion SCys C can be used as a diagnostic indicator of early renal injury in children with bronchial pneumonia.