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海马CA1区神经元对缺血极为敏感,Kirino采用沙土鼠短暂性脑缺血模型率先发现CA1区神经元呈迟发性死亡。近年,各国学者对迟发性神经元死亡(delayed neuronal death,DND)进行了不懈地研究,海马神经元的迟发性死亡表现为坏死与凋亡共存现象。文章综述了引起迟发性神经元死亡的诸多因素,如胶质细胞过度活化
Neurons in the hippocampal CA1 region were extremely sensitive to ischemia. Kirino, the first model of gerbil transient ischemic injury, found that the neurons in the CA1 region were delayed to death. In recent years, scholars from all over the world have studied the delayed neuronal death (DND). The delayed death of hippocampal neurons is the coexistence of necrosis and apoptosis. This article summarizes many factors that cause delayed neuronal death, such as glial activation