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最近的研究表明,钒酸盐有模拟胰岛素的作用,是由于钒酸盐有激素的靶作用,如增加脂肪和肌肉组织中的葡萄糖转运活性,激活糖代谢主要酶系的新合成,肝糖原合成,抑制脂肪分解和其他作用等等,增加钙内流,在血浆膜抑制Ca~(2+)-Mg~(2+)-ATP酶和升高细胞浆的pH。因此,认为钒酸盐是一种广泛的胰岛素模拟剂,有可能用于治疗糖尿病。 为此作者选择用链佐霉素处理的糖尿病小鼠动物模型。在动物饮水中加入0.2mg/ml的钒酸盐钠和80mM氯化钠(可降低钒酸盐毒性)是最适宜的
Recent studies have shown that vanadate has the effect of mimicking insulin due to the hormonal effects of vanadate, such as increasing glucose transport activity in fat and muscle tissue, activating new synthesis of major enzyme systems for glycometabolism, glycogen Synthesis, inhibition of lipolysis and other effects, and so on, increase calcium influx, in the plasma membrane inhibition of Ca ~ (2 +) - Mg ~ (2 +) - ATPase and increase the pH of the cytoplasm. Therefore, vanadate is considered a broad class of insulin mimetics and is potentially useful in the treatment of diabetes. To this end, the authors selected animal models of diabetic mice treated with streptozotocin. It is most suitable to add 0.2 mg / ml sodium vanadate and 80 mM sodium chloride (to reduce vanadate toxicity) in animal drinking water