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目的对胃肠道间质肿瘤的病理形态学与免疫组化的抗体特征进行分析,探讨最佳诊断方法。方法选取2010年1月-2012年1月我院107例胃肠道间质肿瘤患者,均给予光镜观察和免疫组化检测。结果 107例患者中,病灶在胃部59例,在小肠13例,肠系膜13例,结肠12例,直肠10例;恶性40例,潜在性恶性31例,良性36例。胃肠道间质肿瘤较常见于50-70岁人群,男性发病率高于女性。结论胃肠道间质肿瘤多属潜在恶性或者恶性,其组织学形态具有特殊性,免疫组化染色检测在诊断方面具有显著作用,CD117、CD34在诊断胃肠道是否存在间质瘤方面存在特异性,但不能作为判别良恶性的有效指标。
Objective To analyze the pathomorphology of gastrointestinal stromal tumors and the characteristics of immunohistochemical antibodies to explore the best diagnostic method. Methods From January 2010 to January 2012, 107 patients with gastrointestinal stromal tumors in our hospital were examined by light microscopy and immunohistochemistry. Results Of the 107 patients, 59 were in the stomach, 13 in the small intestine, 13 in the mesentery, 12 in the colon, and 10 in the rectum; 40 were malignant, 31 were potentially malignant, and 36 were benign. Gastrointestinal stromal tumors are more common in people aged 50-70, the incidence of men than women. Conclusions Most gastrointestinal stromal tumors are potentially malignant or malignant. The histological morphology of gastrointestinal stromal tumors is special. Immunohistochemical staining has a significant diagnostic value. CD117 and CD34 are specific in the diagnosis of gastrointestinal stromal tumors Sex, but not as a good indicator of benign and malignant.