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目的:评价妥洛特罗贴剂治疗儿童喘息性疾病的有效性、依从性和安全性。方法:试验组(n=13)给予妥洛特罗贴剂治疗,对照组(n=13)给予盐酸丙卡特罗口服溶液治疗,均进行7 d的治疗随访观察,比较2组治疗总有效率、临床评分、患儿用药依从性及用药不良事件。结果:(1)试验组与对照组总有效率分别为92.31%和84.62%,差异无显著性(P<0.05);(2)3次随访,2组临床评分均显著降低(P<0.05);(3)试验组用药依从性优于对照组(P<0.05);(4)2组患儿均未出现严重不良。结论:妥洛特罗贴剂治疗儿童喘息性疾病安全、有效、依从性好,值得临床应用推广。
PURPOSE: To evaluate the efficacy, compliance and safety of the use of tulobuterol in the treatment of wheezing disorders in children. Methods: The experimental group (n = 13) was treated with tulobuterol and the control group (n = 13) with procaterol hydrochloride oral solution. All patients were followed up for 7 days. The total effective rate , Clinical score, medication compliance and medication adverse events in children. Results: (1) The total effective rate of the experimental group and the control group was 92.31% and 84.62%, respectively, with no significant difference (P <0.05); (2) The clinical scores of the two groups were significantly decreased ; (3) The medication compliance of the experimental group was better than that of the control group (P <0.05); (4) No severe adverse reactions occurred in the two groups. Conclusion: The use of tulobuterol patch in the treatment of asthmatic children is safe, effective and good in compliance. It is worth to be popularized in clinical application.