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一、概述: 自1958年病理学家Teare等首先描述青年非对称性心脏肥厚以来,仅仅二十余年的研究,就充分确立本病在心脏疾病中的重要地位。六十年代初Braunwald提出了左室流出道(LVOT)动力性梗阻和特发性肥厚性主动脉瓣下狭窄(IHSS)的命名。1966年Ross等证明了梗阻系心脏收缩时二尖瓣在左室流出道的位置异常引起。七十年代初超声心动图的应用,发现两个重要特征,即非对称性室间隔肥厚(ASH)与收缩期二尖瓣前叶前向运动(SAM),同时证明这种疾病相当普遍,且大多数患者无临床表现。
I. Overview: Since the pathologist Teare et al first described the asymmetric hypertrophic youth in 1958, just over 20 years of research have fully established the importance of this disease in heart disease. Braunwald proposed the designation of left ventricular outflow tract (LVOT) dynamic obstruction and idiopathic hypertrophic aortic valve stenosis (IHSS) in the early 1960s. In 1966, Ross et al. Demonstrated that the mitral valve was caused by anomalous location of the left ventricular outflow tract when the obstruction was systolic. The application of echocardiography in the early seventies found two important characteristics, asymmetric ventricular septal hypertrophy (ASH) and systolic mitral valve anterior forward motion (SAM), while proving that the disease is quite common and that Most patients have no clinical manifestations.