用大剂量钴~(60)照射曼氏血吸虫活尾蚴免疫的小鼠对攻击感染的损耗

• 作 者: 温慧初
• 出 处: 国外医学(寄生虫病分册)
• 发表日期: 1981年06期
• 关键词: 攻击感染 曼氏血吸虫 免疫 伴随免疫 尾蚴 损耗 剂量 童虫 腹部皮肤 用大

在曼氏血吸虫慢性感染而产生伴随免疫的小鼠对激发感染的损耗有二期。早期,在接种后3天,损耗率约为对照的30%,发生于皮肤内,仅在初次感染产卵后开始。晚期,见于攻击感染后6～14天,可杀灭约43%。本实验目的在于检查在大剂量照射尾蚴免疫小鼠是否对攻击感染具有与慢性感染小鼠同样的二个损耗期。

Mice infected with Schistosoma mansoni chronically infected with concomitant immunization had two phases of challenge infection. Early in the day, 3 days after inoculation, the rate of loss was about 30% of the control, which occurred in the skin and started only after the first infection spawned. Late, seen in attack infection 6 to 14 days, can kill about 43%. The purpose of this experiment was to examine whether mice immunized with cercariae irradiated with large doses had the same two loss periods as the challenge-challenged mice with chronic infection.