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使用动脉夹阻断基底动脉和两侧颈总动脉６０ｍｉｎ，然后恢复血供６０ｍｉｎ。在夹闭三血管前１５ｍｉｎ，腹腔注射绞股蓝总皂甙注射液，观察绞股蓝总皂甙对脑缺血再灌注损伤的保护作用。结果发现，绞股蓝总皂甙能显著减轻脑细胞内水、Ｎａ￣＋含量，Ｋ￣＋向细胞外移动减少，细胞内乳酸脱氢酶和肌酸激酶释放明显受抑，脑组织内乳酸积聚显著改善，丙二醛含量显著下降。表明绞股蓝总皂甙对大鼠全脑缺血再灌注损伤有明显保护作用。
Arterial clips were used to block the basilar artery and common carotid arteries on both sides for 60 min, then the blood supply was resumed for 60 min. 15min before clamping the three blood vessels, intraperitoneal injection of gypenosides injection to observe the protective effect of gypenosides on cerebral ischemia-reperfusion injury. The results showed that gypenosides can significantly reduce the water content of brain cells, Na ~ + content, K ~ + to the extracellular movement decreased intracellular lactate dehydrogenase and creatine kinase release significantly inhibited the accumulation of lactate in brain tissue was significantly improved , Malondialdehyde content decreased significantly. Gynostemma saponins on rat cerebral ischemia-reperfusion injury have obvious protective effect.