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目的:分析重症肌无力(MG)患者胸腺切除后合并视神经脊髓炎的临床特点,探讨两者合并发生的机制。方法:结合文献对1例MG胸腺切除后合并视神经脊髓炎患者的临床特点和血清学改变进行分析。结果:现有的MG合并视神经脊髓炎的文献报道中,绝大多数(13/15例)在胸腺切除后发生。胸腺切除后抑制T细胞产生减少,B细胞过度增殖,自身免疫抗体增加,可能与视神经脊髓炎的发病有关。此外,HLAB8、DR2和DR3也可能与MG合并视神经脊髓炎的发生相关。结论:MG患者胸腺切除后引起的免疫系统改变(如血清中抑制T细胞数的改变和自身抗体的出现),患者的HLA抗原类型(如HLA-B8、DR2和DR3)可能与合并视神经脊髓炎的发生相关。
Objective: To analyze the clinical characteristics of myasthenia gravis after thymectomy in patients with myasthenia gravis (MG) and to explore the mechanism of their combination. Methods: The clinical features and serological changes of one patient with MG after thymectomy combined with literature were analyzed. Results: Most of the reported reports of MG with optic neuromyelitis occurred in 13/15 cases after thymectomy. Inhibition of thymus after T cells reduce the production of B cells over-proliferation, increased autoimmune antibodies, may be related to the pathogenesis of optic neuromyelitis. In addition, HLAB8, DR2 and DR3 may also be associated with MG with optic neuromyelitis. CONCLUSIONS: Immune system changes following thymectomy in MG patients (such as changes in serum T-cell counts and the appearance of autoantibodies), and the type of HLA antigens (eg HLA-B8, DR2 and DR3) in patients with MG may be associated with optic neuromyelitis Related to the occurrence of.