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目的探讨坎地沙坦对原发性高血压患者血压晨峰的临床疗效。方法采用动态血压监测诊断为血压晨峰的患者96例,对其中43例采用每天早晨服药治疗(早晨服药组),53例采用每天晚上服药(晚间服药组)。均为每天服坎地沙坦8mg加氢氯噻嗪12.5～25mg。疗程2月,观察对24h平均血压及血压晨峰的降压疗效及药物不良反应。结果两组治疗2月后24h平均血压均有明显降低,两组无显著性差异(p>0.05).但晚上服药组血压晨峰比早晨服药组血压降低较明显,两组有显著性差异(p<0.05)。两组对药物不良反应均少,组间无显著性差异。结论坎地沙坦+氢氯噻嗪能明显降低24h平均血压(包括收缩压与舒张压),而夜间服药比早晨服药能更好地降低血压晨峰。
Objective To investigate the clinical effect of candesartan on the morning peak of blood pressure in patients with essential hypertension. Methods Ninety-six patients were diagnosed as ambulatory blood pressure by ambulatory blood pressure monitoring. Forty-three patients were treated with morning medication every morning (morning medication group) and 53 patients with evening medication (evening medication group). Each day isosulfan 8mg hydrochlorothiazide 12.5 ~ 25mg. Course of treatment in February, the mean blood pressure and blood pressure 24h observation of antihypertensive efficacy and adverse drug reactions. Results The average blood pressure was significantly lower at 24h after 2 months of treatment in both groups (p> 0.05), but the morning blood pressure of morning medication group was significantly lower than that of morning medication group, and there was significant difference between the two groups p <0.05). Adverse reactions to both drugs were less, no significant difference between the two groups. Conclusions Candesartan + hydrochlorothiazide can significantly reduce the average blood pressure of 24h (including systolic and diastolic blood pressure), while taking the drug at night can reduce the morning peak of blood pressure better than taking it in the morning.