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目的:探讨血浆内皮祖细胞(EPCs) CD34+水平与新疆哈萨克族(哈族)原发性高血压病患者血压、血脂、血糖、肥胖等的相关性。方法:选取新疆哈族原发性高血压患者87为观察组,哈族健康对照组79例,测量血压(BP)、身高、体重、腰围(WC)、臀围(HC),抽取空腹静脉血测定血糖(FPG)、总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C),计算体重指数(BMI)腰臀比(WHR)。结果:①原发性高血压组血浆EPCs CD34+水平明显低于对照组(p<0.01)②原发性高血压组血浆EPCs CD34+水平与收缩压、舒张压、总胆固醇、甘油三酯、低密度脂蛋白胆固醇、血糖、体重指数呈显著负相关。对照组血浆EPCsCD34+水平与收缩压、舒张压、总胆固醇、甘油三酯、体重指数呈负相关。③多元回归分析显示在原发性高血压组中收缩压、甘油三酯是影响血浆EPCs CD34+水平的独立因素,在对照组中总胆固醇、体重指数是影响血浆EPCs CD34+水平水平的独立因素。结论:哈族原发性高血压患者血浆EPCs CD34+水平与血压水平存在一定的相关性。
Objective: To investigate the correlation between CD34 + levels of plasma EPCs and blood pressure, blood lipid, blood sugar and obesity in Kazakh patients with essential hypertension. Methods: Eighty-seven patients with essential hypertension in Xinjiang Kazakh ethnic group were selected as the observation group and 79 healthy controls. The blood pressure (BP), height, weight, waist circumference (WC), hip circumference (HC) The levels of blood glucose (FPG), total cholesterol (TC), triglyceride (TG), high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL- (WHR). Results: ① The plasma levels of EPCs CD34 + in patients with essential hypertension were significantly lower than those in controls (p <0.01). ② The correlations of plasma CD34 + levels of EPCs with systolic blood pressure, diastolic blood pressure, total cholesterol, triglycerides, Lipoprotein cholesterol, blood glucose, body mass index was significantly negatively correlated. The plasma levels of EPCs CD34 + in the control group were negatively correlated with systolic blood pressure, diastolic blood pressure, total cholesterol, triglycerides and body mass index. ③ Multiple regression analysis showed that systolic blood pressure in patients with primary hypertension, triglycerides were independent factors affecting the level of plasma CD34 + EPCs. In the control group, total cholesterol and body mass index were independent factors affecting the levels of plasma CD34 + EPCs. Conclusion: There is a certain correlation between plasma CD34 + levels and blood pressure level in patients with essential hypertension in Kazakh ethnic group.