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目的 探讨老年胆总管结石患者行治疗性内镜逆行性胰胆管造影术（ERCP）的临床护理方法及效果。方法 选择医院2019年1月至2020年9月收治的76例老年胆总管结石行治疗性ERCP术患者，按照住院先后的顺序分为两组，每组38例。对照组予以常规护理，观察组予以围手术期综合护理干预。比较两组患者术后肛门排气时间、住院时间、并发症情况。结果 观察组患者术后肛门排气时间与住院时间分别为（15.62±3.14）h、（6.52±1.29）d，对照组依次为（20.67±3.91）h、（9.20±1.16）d，观察组明显短“,”Objective To explore the clinical nursing methods and effects of therapeutic endoscopic retrograde cholangiopancreatography (ERCP) in elderly patients with common bile duct stones. Methods A total of 76 elderly patients with common bile duct stones undergoing therapeutic ERCP who were admitted to our hospital from January 2019 to September 2020 were divided into two groups according to the order of hospitalization， with 38 cases in each group. The control group received routine nursing care， and the observation group received comprehensive perioperative nursing intervention. The postoperative anal exhaust time， hospital stay， and complications were compared between the two groups. Results The postoperative anal exhaust time and hospitalization time of the observation group were (15.62±3.14) h and (6.52±1.29) d， respectively， and the control group were (20.67±3.91) h and (9.20±1.16) d. The observation group was significantly shorter than the control group， the difference was statistically significant (P ＜0.05). The 12 h postoperative VAS scores of the observation group and the control group were higher than those of the preoperative and 24 h postoperative (P ＜0.05); the observation group had no significant difference in the preoperative VAS scores of the control group significance (P ＞0.05); the VAS scores of the observation group at 12 h and 24 h after surgery were lower than those of the control group (P ＜0.05); the preoperative GIQLI score of the observation group was not significantly different from that of the control group (P ＞0.05); the observation group the GIQLI scores at 1 and 2 months after operation were higher than those in the control group and before operation (P ＜0.05); there was no significant difference in the levels of bilirubin， ALT and AST in the observation group before and 3 days after operation and the control group significance (P ＞0.05). The levels of bilirubin， ALT， and AST at 3 days postoperatively in the observation group and the control group were lower than those before the operation (P ＜0.05). The complication rate of the observation group was 2.63%， and the control group was 18.42%， the observation group was significantly lower than the control group， and the difference between the groups was statistically significant (P ＜0.05). Conclusion The comprehensive perioperative nursing intervention for elderly patients with choledocholithiasis undergoing therapeutic ERCP can not only shorten the postoperative recovery time， reduce the occurrence of complications， relieve pain， but also improve the quality of life.