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近几年来已发现多种干扰素诱导物可引起肝微粒体细胞色素 P-450的含量和活性下降,并认为这是干扰素诱导物的一个共同特征。为了搞清此作用是由于干扰素本身还是继发的免疫反应所致,本文作者选用了两种特殊种系的小鼠:C57BL/6J 和C_3H/HeJ,前者在 IF-1位点上携带有高产量干扰素的等位基因(IF-1~h),而后者在同一位点上带有低产量干扰素的等位基因(IH-1~1),以确定细胞色素 F-450的含量和活性变化与血清干扰素水平的关系。
In recent years, it has been found that a variety of interferon inducers can cause a decrease in the content and activity of liver microsomal cytochrome P-450 and are considered as a common feature of interferon inducers. In order to find out whether this effect is due to interferon itself or secondary immune response, the authors selected two special germline mice: C57BL / 6J and C_3H / HeJ, the former carrying IF-1 The high yield interferon allele (IF-1 ~ h), while the latter has a low yield of interferon allele (IH-1 ~ 1) at the same locus to determine the cytochrome F-450 content And the relationship between activity changes and serum interferon levels.