Asymmetric Syntheses of Osmundalactones and 5-Hydroxy-2-hexen-4-olides from 4-Benzyloxy-5-hydroxy-2(

• 作 者: Machiko ONO Hiroyuki AKITA
• 机 构: School of Pharmaceutical Sciences Toho University Chiba 274-8510 Japan,School of Pharmaceutical Sci
• 出 处: Chinese Chemical Letters
• 发表日期: 2006年06期
• 关键词: lactone acetoxy xylene pyridine unsaturated larvae yellow lipase hydrolyzed star

(+)-(4S,5R)- and (-)-(4R,5S)-osmundalactones as well as (+)-(4R,5S)- and (-)-(4S,5R)- 5-hydroxy-2-hexen-4-olides were synthesized by a concise and efficient synthesis method starting from 4-benzyloxy-5-hydroxy-2(E)-hexenoate in good yield with over 99% e.e..

(-) - (4R, 5S) -osmundalactones as well as (+) - (4S, 5R) 2-hexen-4-olides were synthesized by a concise and efficient synthesis method starting from 4-benzyloxy-5- hydroxy-2 (E) -hexenoate in good yield with over 99% ee.